Hesselgesser, J.: search on Z-Library

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1

1129 PRECLINICAL CHARACTERIZATION OF GS-9620, A POTENT AND SELECTIVE ORAL TLR7 AGONIST

Turnas, P., Zheng, X., Lu, B., Rhodes, G., Duatschek, P., Hesselgesser, J., Frey, C., Henne, I., Fosdick, A., Halcomb, R., Wolfgang, G.

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

2

Interleukin-1β induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors

Neil G. Miyamoto, Poonam S. Medberry, Joe Hesselgesser, Sabine Boehlk, Peter J. Nelson, Alan M. Krensky, H.Daniel Perez

Journal:

Journal of Neuroimmunology

Year:

2000

Language:

english

File:

PDF, 1.22 MB

english, 2000

3

455 GS-9620 INDUCES A PRESYSTEMIC INNATE IMMUNE RESPONSE IN THE ABSENCE OF SERUM INTERFERON OR ADVERSE EFFECTS IN BOTH NON-CLINICAL SPECIES AND HUMANS

D. Tumas, A. Fosdick, X. Zheng, R. Lanford, J. Hesselgesser, C. Frey, W. Grushenka, R. Halcomb, U. Lopatin

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 74 KB

english, 2012

4

Vesatolimod (GS-9620) is safe and pharmacodynamically active in HIV-infected individuals

Riddler, S., Para, M., Benson, C., Mills, A., Ramgopal, M., Dejesus, E., Brinson, C., Cyktor, J., Mellors, J., Guo, S., Doehle, B., Markova, S., Patel, H., Graham, H., Hesselgesser, J., Geleziunas, R.

Journal:

Journal of Virus Eradication

Year:

2019

File:

PDF, 89 KB

2019

5

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

Bam, Rujuta A., Hansen, Derek, Irrinki, Alivelu, Mulato, Andrew, Jones, Gregg S., Hesselgesser, Joseph, Frey, Christian R., Cihlar, Tomas, Yant, Stephen R.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1000 KB

english, 2016

6

The solubility of some minerals in superheated steam at high pressures

Morey, G. W., Hesselgesser, J. M.

Journal:

Economic Geology

Year:

1951

Language:

english

File:

PDF, 255 KB

english, 1951

7

[Methods in Enzymology] Chemokines Volume 287 || Alanine scan mutagenesis of chemokines

Hesselgesser, Joseph

Year:

1997

Language:

english

File:

PDF, 1.28 MB

english, 1997

8

CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis

Corinna Trebst, Torben Lykke Sørensen, Pia Kivisäkk, Martha K. Cathcart, Joseph Hesselgesser, Richard Horuk, Finn Sellebjerg, Hans Lassmann, Richard M. Ransohoff

Journal:

The American Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 1.11 MB

english, 2001

9

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4

Joseph Hesselgesser, Dennis Taub, Padmavathi Baskar, Michael Greenberg, James Hoxie, Dennis L. Kolson, Richard Horuk

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 88 KB

english, 1998

10

Discovery of Novel Non-Peptide CCR1 Receptor Antagonists

Ng, Howard P., May, Karen, Bauman, John G., Ghannam, Ameen, Islam, Imadul, Liang, Meina, Horuk, Richard, Hesselgesser, Joseph, Snider, R. Michael, Perez, H. Daniel, Morrissey, Michael M.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

11

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

Wei, Datsen George, Chiang, Vicki, Fyne, Elizabeth, Balakrishnan, Mini, Barnes, Tiffany, Graupe, Michael, Hesselgesser, Joseph, Irrinki, Alivelu, Murry, Jeffrey P., Stepan, George, Stray, Kirsten M.,

Journal:

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

12

CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2

Marina Molino, Marilyn J. Woolkalis, Nicolas Prevost, Domenico Praticó, Elliot S. Barnathan, Giulia Taraboletti, Beth Stobenau Haggarty, Joseph Hesselgesser, Richard Horuk, James A. Hoxie, Lawrence F.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2000

Language:

english

File:

PDF, 640 KB

english, 2000

13

The Duffy antigen receptor for chemokines: structural analysis and expression in the brain

Horuk, R., Martin, A., Hesselgesser, J., Hadley, T., Lu, Zhao-hai, Wang, Zi-xuan, Peiper, S. C.

Journal:

Journal of Leukocyte Biology

Year:

1996

Language:

english

File:

PDF, 1.60 MB

english, 1996

14

Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation

Liu, Po-Ting, Keele, Brandon F., Abbink, Peter, Mercado, Noe B., Liu, Jinyan, Bondzie, Esther A., Chandrashekar, Abishek, Borducchi, Erica N., Hesselgesser, Joseph, Mish, Michael, Chin, Gregory, Beker

Journal:

Nature Communications

Year:

2020

File:

PDF, 1017 KB

2020

15

CD4-independent association between HIV-1 gp120 and CXCR4: Functional chemokine receptor expression in human neurons

J. Hesselgesser, M. Halks-Miller, V. DelVecchio, S.C. Peiper, J. Hoxie, D.L. Kolson, D. Taub, R. Horuk

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 172 KB

english, 1997

16

CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model

Richard Horuk, Sandra Shurey, Howard P Ng, Karen May, John G Bauman, Imadul Islam, Ameen Ghannam, Brad Buckman, Guo Ping Wei, Wei Xu, Meina Liang, Mary Rosser, Laura Dunning, Joseph Hesselgesser, R.Mi

Journal:

Immunology Letters

Year:

2001

Language:

english

File:

PDF, 311 KB

english, 2001

17

A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein

Tina M. Calderon, Eliseo A. Eugenin, Lillie Lopez, Sridhar Sampath Kumar, Joseph Hesselgesser, Cedric S. Raine, Joan W. Berman

Journal:

Journal of Neuroimmunology

Year:

2006

Language:

english

File:

PDF, 687 KB

english, 2006

18

Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons

C.M Coughlan, C.M McManus, M Sharron, Z.-Y Gao, D Murphy, S Jaffer, W Choe, W Chen, J Hesselgesser, H Gaylord, A Kalyuzhny, V.M.-Y Lee, B Wolf, R.W Doms, D.L Kolson

Journal:

Year:

2000

Language:

english

File:

PDF, 690 KB

english, 2000

19

A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria

Hesselgesser, J., Chitnis, C., Miller, L., Yansura, D., Simmons, L., Fairbrother, W., Kotts, C., Wirth, C., Gillece-Castro, B., Horuk, R.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 12.93 MB

english, 1995

20

The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer

Arenberg, Douglas A., Polverini, Peter J., Kunkel, Steven L., Shanafelt, Armen, Hesselgesser, Joseph, Horuk, Richard, Strieter, Robert M.

Journal:

Journal of Leukocyte Biology

Year:

1997

Language:

english

File:

PDF, 1.56 MB

english, 1997

21

Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo

Philip Meuleman, Joseph Hesselgesser, Matthew Paulson, Thomas Vanwolleghem, Isabelle Desombere, Hans Reiser, Geert Leroux-Roels

Journal:

Year:

2008

Language:

english

File:

PDF, 290 KB

english, 2008

22

Chemokine and chemokine receptor expression in the central nervous system

Hesselgesser, Joseph, Horuk, Richard

Journal:

Journal of NeuroVirology

Year:

1999

Language:

english

File:

PDF, 1.66 MB

english, 1999

23

Search for small molecule activators of latent HIV

Geleziunas, Romas, Stepan, George, Wei, George, Yu, Helen, Graupe, Michael, Pagratis, Nikos, Barnes, Tiffany, Cihlar, Tomas, Hesselgesser, Joe

Journal:

Year:

2012

Language:

english

File:

PDF, 72 KB

english, 2012

24

Chemokine and Chemokine-Receptor Expression in Human Glial Elements: Induction by the HIV Protein, Tat, and Chemokine Autoregulation

Carrie M. McManus, Karen Weidenheim, Scott E. Woodman, Jeranil Nunez, Joseph Hesselgesser, Avindra Nath, Joan W. Berman

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 2.35 MB

english, 2000

25

Clinical experience with the oxytocin challenge test

Ray, Michael, Freeman, Roger, Pine, Stephen, Hesselgesser, Robert

Journal:

American Journal of Obstetrics and Gynecology

Year:

1972

Language:

english

File:

PDF, 1.49 MB

english, 1972

26

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeficiency Virus Type 1 Integrase

Jones, G. S., Yu, F., Zeynalzadegan, A., Hesselgesser, J., Chen, X., Chen, J., Jin, H., Kim, C. U., Wright, M., Geleziunas, R., Tsiang, M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 2.31 MB

english, 2009

27

Alanine mutagenesis of MGSA identifies specific amino acids that bind to the duffy antigen/chemokine receptor and the IL-8 receptor

R. Horuk, J. Hesselgesser, D. Yansura, L. Simmons, W. Fairbrother, C. Kotts, C. Wirth, B. Gillece-Castro, C. Chitnis, L. Miller

Journal:

Year:

1994

Language:

english

File:

PDF, 154 KB

english, 1994

28

Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses

Fosdick, A., Zheng, J., Pflanz, S., Frey, C. R., Hesselgesser, J., Halcomb, R. L., Wolfgang, G., Tumas, D. B.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 786 KB

english, 2013

29

CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

Joseph Hesselgesser, Meredith Halks-Miller, Virginia DelVecchio, Stephen C. Peiper, James Hoxie, Dennis L. Kolson, Dennis Taub, Richard Horuk

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 228 KB

english, 1997

30

Clinical experience with the oxytocin challenge test

Michael Ray, Roger Freeman, Stephen Pine, Robert Hesselgesser

Journal:

American Journal of Obstetrics and Gynecology

Year:

1995

Language:

english

File:

PDF, 57 KB

english, 1995

31

The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains

Horuk, R., Hesselgesser, J., Zhou, Y., Faulds, D., Halks-Miller, M., Harvey, S., Taub, D., Samson, M., Parmentier, M., Rucker, J., Doranz, B. J., Doms, R. W.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 711 KB

english, 1998

32

Clinical experience with the oxytocin challenge test

Michael Ray, Roger Freeman, Stephen Pine, Robert Hesselgesser

Journal:

American Journal of Obstetrics and Gynecology

Year:

1995

Language:

english

File:

PDF, 38 KB

english, 1995

33

Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Roethle, Paul A., McFadden, Ryan M., Yang, Hong, Hrvatin, Paul, Hui, Hon, Graupe, Michael, Gallagher, Brian, Chao, Jessica, Hesselgesser, Joseph, Duatschek, Paul, Zheng, Jim, Lu, Bing, Tumas, Daniel B

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 658 KB

english, 2013

34

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

Lopatin, Uri, Wolfgang, Grushenka, Tumas, Daniel, Frey, Christian R, Ohmstede, Carol, Hesselgesser, Joseph, Kearney, Brian, Moorehead, Lisa, Subramanian, G Mani, McHutchison, John G

Journal:

Antiviral Therapy

Year:

2013

Language:

english

File:

PDF, 353 KB

english, 2013

35

Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor

Meina Liang, Mary Rosser, Howard P Ng, Karen May, John G Bauman, Imadul Islam, Ameen Ghannam, Peter J Kretschmer, Haifeng Pu, Laura Dunning, R.Michael Snider, Michael M Morrissey, Joseph Hesselgesser,

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 560 KB

english, 2000

36

The Solution Structure of Melanoma Growth Stimulating Activity

Wayne J. Fairbrother, Dorothea Reilly, Timothy J. Colby, Joseph Hesselgesser, Richard Horuk

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 1.42 MB

1994

37

The Promiscuous Chemokine Binding Profile of the Duffy Antigen/Receptor for Chemokines Is Primarily Localized to Sequences in the Amino-terminal Domain

Zhao-hai, L., Zi-xuan, W., Horuk, R., Hesselgesser, J., Yan-chun, L., Hadley, T. J., Peiper, S. C.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 678 KB

english, 1995

38

Comparative evaluation of co-formulated injectable combination antiretroviral therapy regimens in SIV-infected rhesus macaques

Del Prete, Gregory, Smedley, Jeremy, Macallister, Rhonda, Jones, Gregg, Li, Bei, Hattersley, Jillian, Zheng, Jim, Piatak, Michael, Keele, Brandon, Hesselgesser, Joseph, Geleziunas, Romas, Lifson, Jeff

Journal:

AIDS Research and Human Retroviruses

Year:

2015

Language:

english

File:

PDF, 695 KB

english, 2015

39

Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor

Hesselgesser, Joseph, Ng, Howard P., Liang, Meina, Zheng, Wei, May, Karen, Bauman, John G., Monahan, Sean, Islam, Imadul, Wei, Guo Ping, Ghannam, Ameen, Taub, Dennis D., Rosser, Mary, Snider, R. Micha

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 477 KB

english, 1998

40

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

Lim, So-Yon, Osuna, Christa E., Hraber, Peter T., Hesselgesser, Joe, Gerold, Jeffrey M., Barnes, Tiffany L., Sanisetty, Srisowmya, Seaman, Michael S., Lewis, Mark G., Geleziunas, Romas, Miller, Michae

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 3.45 MB

english, 2018

41

CXCR3 expression in human central nervous system diseases

S. H. Goldberg, P. Van Der Meer, J. Hesselgesser, S. Jaffer, D. L. Kolson, A. V. Albright, F. González-Scarano, E. Lavi

Journal:

Neuropathology and Applied Neurobiology

Year:

2001

Language:

english

File:

PDF, 524 KB

english, 2001

42

Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation

Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R. L., Moore, M. A.S., Rafii, S.

Journal:

Journal of Experimental Medicine

Year:

1998

Language:

english

File:

PDF, 560 KB

english, 1998

43

Immunohistochemical Analysis of CXCR3 Expression in Human Central Nervous System Diseases

Goldberg, S. H., Hesselgesser, J., Ulrich, A. M., Jaffer, S., Kolson, D. L., Albright, A. V., Gonzalez-Scarano, F., Lavi, E.

Journal:

Journal of Neuropathology and Experimental Neurology

Year:

1999

File:

PDF, 109 KB

1999

44

PD-1 blockade and TLR7 activation lack therapeutic benefit in chronic SIV-infected macaques on antiretroviral therapy

Bekerman, Elena, Hesselgesser, Joseph, Carr, Brian, Nagel, Mark, Hung, Magdeleine, Wang, Adele, Stapleton, Lance, von Gegerfelt, Agneta, Elyard, Hanne Andersen, Lifson, Jeffrey D., Geleziunas, Romas

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2019

Language:

english

File:

PDF, 3.51 MB

english, 2019

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